Effect of Bacterial Translocation on Haemodynamic and Coagulation Parameters During Liver Transplantation

Alexandria University

Status: Completed

Conditions: Effect of Bacterial Translocation

Treatments: Diagnostic Test: PCR for bacterial translocation

Study type: Observational

Funder types: Other

Identifiers

NCT03230214

020583

Details and patient eligibility

About

The present study is to demonstrate the effect of the presence of bacterial translocation detected by bacterial deoxyribonucleic acid (bactDNA) in blood and ascites using the polymerase chain reaction (PCR) on some haemodynamic and coagulation parameters during a liver transplant procedure.

Enrollment: 30 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with liver failure undergoing liver transplantation

Exclusion criteria

• Age less than 18 years;
• Active overt infection;
• Patients on oral or systemic anticoagulation or with known coagulopathic disorders apart from those caused by liver failure (eg.: Protein C or S deficiency, congenital platelet disorders and congenital coagulation disorders...etc);
• Patients undergoing re-transplantation.

Trial design

30 participants in 2 patient groups

DNA positive patients

Description:

patients who have bacterial DNA in their samples

Treatment:

Diagnostic Test: PCR for bacterial translocation

DNA negative patients

Description:

patients who do not have bacterial DNA in their samples

Treatment:

Diagnostic Test: PCR for bacterial translocation