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Effect of Bacterial Translocation on Haemodynamic and Coagulation Parameters During Liver Transplantation

A

Alexandria University

Status

Completed

Conditions

Effect of Bacterial Translocation

Treatments

Diagnostic Test: PCR for bacterial translocation

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

The present study is to demonstrate the effect of the presence of bacterial translocation detected by bacterial deoxyribonucleic acid (bactDNA) in blood and ascites using the polymerase chain reaction (PCR) on some haemodynamic and coagulation parameters during a liver transplant procedure.

Enrollment

30 patients

Sex

All

Ages

20 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

• patients with liver failure undergoing liver transplantation

Exclusion criteria

  • Age less than 18 years;
  • Active overt infection;
  • Patients on oral or systemic anticoagulation or with known coagulopathic disorders apart from those caused by liver failure (eg.: Protein C or S deficiency, congenital platelet disorders and congenital coagulation disorders...etc);
  • Patients undergoing re-transplantation.

Trial design

30 participants in 2 patient groups

DNA positive patients
Description:
patients who have bacterial DNA in their samples
Treatment:
Diagnostic Test: PCR for bacterial translocation
DNA negative patients
Description:
patients who do not have bacterial DNA in their samples
Treatment:
Diagnostic Test: PCR for bacterial translocation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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