Effect of Bariatric Surgery on Blood Pressure (BASBP)

Zhiming Zhu

Status: Unknown

Conditions: Diabetes; Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT02050984

BASBP

2012CB517805 (Other Grant/Funding Number)

Details and patient eligibility

About

Bariatric surgery is generally recommended for obese people with a body mass index (BMI) of at least 40kg/m2, and for people with BMI 35 kg/m2 and serious coexisting medical conditions such as diabetes. A variety of studies showed that it cause significant weight loss, recovery from diabetes and improvement in cardiovascular risk factors, such as blood pressure. The recent guidelines suggest that patients with a BMI of more than 30 kg/m2 with co morbidities is a candidate for bariatric surgery. However, the patients with diabetes in Chinese has lower BMI than that in west country. Therefore, this research is designed to observe whether bariatric surgery reduce blood pressure in patients with diabetes and relatively lower BMI.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged between 18 and 60 years old.
• Type 2 Diabetes diagnosis defined according to WHO 2006 guideline.
• Body mass index between 25.0 and 39.9 kg/m2.

Exclusion criteria

• Hypertension ≥ 180/120 mmHg;
• Type 1 diabetes, other types of diabetes or gestational diabetes;
• Acute complications of diabetes;
• Cerebrovascular diseases in the last 6 months.
• Cardiovascular diseases (myocardial infarction, angina, cardiac failure) in the last 6 months.
• Baseline psychiatric disorders: schizophrenia, bipolar disorder, severe depression, psychosis.
• Renal diseases: diabetic nephropathy, creatinine clearance < 30 ml/min.
• Advanced peripheral arterial disease
• Atrophic gastritis
• Alcoholism or use of illicit drugs
• Previous laparotomy
• Severe hepatic disorders
• Pregnancy or women not using effective contraceptive methods.
• Recent neoplasm (< 5 years)
• Immunosuppressant drugs
• Unable to understanding and follow the study protocol orientations.