Effect of Bariatric Surgery on Kidney Function (GAS)

Steno Diabetes Centers

Status: Completed

Conditions: Obese Subjects Who Will Undergo Gastric By-pass Surgery

Treatments: Procedure: Gastric by-pass surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT02138565

3005

Details and patient eligibility

About

Primary hypothesis:

A large reduction in weight is not associated with a change in accurately measured glomerular filtration rate (GFR) (51Chromium ethylenediaminetetraacetic acid plasma clearance (51Cr-EDTA)).

Secondary hypothesis:

A large reduction in weight is associated with a greater change in estimated GFR (The Modification of Diet in Renal Disease (MDRD-formula)) than in accurately measured GFR.

Other formulas for estimated GFR (Cockcroft Gault, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI with cystatin C) are better correlated with accurately measured GFR.

Enrollment: 20 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female, older than 18 years of age
• Appointed to gastric by-pass surgery on Hvidovre Hospital, Denmark

Exclusion criteria

• Withdrawal of surgical indication
• Severe oedema or ascites

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Bariatric surgery

Experimental group

Treatment:

Procedure: Gastric by-pass surgery