Effect of Barley Supplemented Wheat Bread on Markers of Cardiovascular and Renal Health

Khyber Medical University Peshawar

Status: Completed

Conditions: Kidney Diseases; Cardiovascular Diseases

Treatments: Other: Effect of Barley Supplemented Wheat Bread on markers of Cardiovascular and Renal Health

Study type: Interventional

Funder types: Other

Identifiers

NCT05312788

KMU/IBMS/IRBE/2022/9302

Details and patient eligibility

About

The disruption of colonic microbiota has been linked to a number of diseases, mainly cardiovascular and kidney diseases. One possible means to improve the microbiota is to increase dietary fiber intake as the intake of dietary fiber shifts the fermentation from proteolytic saccharolytic fermentation.

Beta-glucans are soluble dietary fibers mainly found in oats and barley. Results from previous studies suggest that the consumption of barley reduces the risk of cardiovascular and kidney diseases. Therefore, this study will explore the effect of barley beta-glucans on markers of Cardiovascular and Renal health.

Enrollment: 25 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy individuals of age 18 years or older
• BMI ranged between 18.5 and 24.9

Exclusion criteria

• Celiac disease, Cancer, Diabetes , cardiovascular diseases
• Gastro intestinal tract disease
• Pregnant women
• Use of pre-, pro- or antibiotics 15 days before the enrollment into the study
• Food allergy to food used in the trial

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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25 participants in 2 patient groups, including a placebo group

Whole wheat bread

Placebo Comparator group

Description:

Whole wheat bread will be used as control bread.

Treatment:

Other: Effect of Barley Supplemented Wheat Bread on markers of Cardiovascular and Renal Health

Barley supplemented wheat bread

Experimental group

Description:

Barley supplemented wheat bread (50% substitution) will be used as experimental bread.

Treatment:

Other: Effect of Barley Supplemented Wheat Bread on markers of Cardiovascular and Renal Health