Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function

University of Florida

Status: Enrolling

Conditions: Coronary Artery Disease

Treatments: Dietary Supplement: Nitrate rich beetroot juice; Dietary Supplement: Nitrate depleted beetroot juice

Study type: Interventional

Funder types: Other

Identifiers

NCT04920799

IRB202100040

Details and patient eligibility

About

Older adults with coronary artery disease (CAD) have impaired vascular and inspiratory muscle function. The objective of this study is to examine the effect of beet juice supplementation on vascular and inspiratory muscle function in older adults with CAD.

Enrollment: 24 estimated patients

Sex: All

Ages: 60 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults with coronary artery disease (CAD) based on an angiogram >50% stenosis in any major epicardial vessel or history of myocardial infarction or history of coronary revascularization.
• Considered to have stable CAD on optimal medical therapy
• 60 to 85 years of age
• Men and women (women must be postmenopausal either natural or surgical)
• Able to give consent

Exclusion criteria

• Ejection fraction <50%, unstable angina, recent myocardial infarction within 6 months
• Coronary revascularization, including percutaneous coronary intervention and coronary artery bypass graft or thoracic surgery within 6 months.
• Stroke, obstructive pulmonary disease, hepatitis B, C, HIV, seizures, or other relevant on-going or recurrent illness
• Individuals that have participated in respiratory training within the last 12 months or cardiac rehabilitation within the last 6 months
• Uncontrolled hypertension
• Use of tobacco products including smoking traditional or e-cigarettes
• Use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone)
• Regular aerobic exercise training
• Unwilling to stop using mouthwash at least 1 week before the start of the study and during study participation
• Unwilling to remain weight stable during study participation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

---

24 participants in 2 patient groups, including a placebo group

Nitrate rich beetroot juice

Active Comparator group

Treatment:

Dietary Supplement: Nitrate rich beetroot juice

Nitrate depleted beetroot juice

Placebo Comparator group

Treatment:

Dietary Supplement: Nitrate depleted beetroot juice