Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue

Wake Forest University (WFU)

Status: Enrolling

Conditions: Health Care Utilization; Healthy Aging

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Beet-root juice; Radiation: red-light therapy; Radiation: sham light

Study type: Interventional

Funder types: Other

Identifiers

NCT05596474

IRB00024675

Details and patient eligibility

About

The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question:

Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement?

Does red light therapy improve forearm muscle endurance compared to a sham light exposure?

Does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?

Enrollment: 10 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Self-reports performing at least 30 minutes of light to moderate intensity physical activity 3 times per week for the last three months

Exclusion criteria

• Currently smoke
• Have smoked within the last 6 months
• Are taking taking supplements known to increase blood nitrate levels
• Have a known kidney disease
• Have a known liver disease
• Have a known thyroid condition
• Have a known gastritis condition
• Are taking medications that are known to cause complications with nitrate supplementation
• Have known or reported joint pain within the dominant hand

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 4 patient groups, including a placebo group

Beet-root juice plus red-light therapy

Experimental group

Treatment:

Radiation: red-light therapy

Dietary Supplement: Beet-root juice

Beet-root juice plus sham light therapy

Sham Comparator group

Treatment:

Radiation: sham light

Dietary Supplement: Beet-root juice

Placebo plus red-light therapy

Placebo Comparator group

Treatment:

Radiation: red-light therapy

Dietary Supplement: Placebo

Placebo plus sham light therapy

Active Comparator group

Treatment:

Radiation: sham light

Dietary Supplement: Placebo