Effect of Biologic Therapy on Surgical Outcomes for Perforated Crohn's Patients

Zagazig University

Status and phase: Completed; Early Phase 1

Conditions: Crohn Disease

Treatments: Biological: early biologic therapy; Biological: late biologic therapy

Study type: Observational

Funder types: Other

Identifiers

NCT06511921

#479\9-July-2024

Details and patient eligibility

About

crohn's disease patients who present by intestinal perforation as the first presentation are hard to deal with. Surgical techniques as anastmosis or diversion stoma and active course of the disease may greatly affect the quality of life. In post-operative period, is the priority to avoid the post operative complications and to improve surgical outcomes or to stop active course of the disease and to induce remission?. So, those patients were classified into two groups. one group received biological therapy early post operative and the other group received it 2 or 3 months later after surgery and the investigators will compare results between the two groups.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients at or above 18 years old
• patients with perforated bowel diagnosed as Crohn's disease at presentation underwent surgery

Exclusion criteria

• patients less than 18 years old
• well known Crohn's disease patients on medical treatment
• associated bowel disease as malignancy and diverticulosis.

Trial design

60 participants in 2 patient groups

post operative Crohn's patients

Treatment:

Biological: early biologic therapy

post operative Cronn's patients

Treatment:

Biological: late biologic therapy