Effect of Blood Flow Restriction Training to Muscle Strength, Dynamic Stability, and ACL Injury Prevention

Udayana University

Status: Enrolling

Conditions: Sports Level 1; Healthy Subjects

Treatments: Procedure: High-load Eccentric training; Procedure: Sham Low-load Blood Flow Restriction training; Procedure: Low-load Blood Flow Restriction training

Study type: Interventional

Funder types: Other

Identifiers

NCT05951036

1575/UN14.2.2.VII.14/LT/2023

Details and patient eligibility

About

The goal of this randomized clinical trial study is to compare low-load blood flow restriction (LL-BFRt), sham LL-BFRt, and high-load eccentric training (HL-Et) in healthy level 1 sportsman. The main questions it aims to answer are:

1. Does LL-BFR improve muscle strength better than sham LL-BFRt and HL-Et?
2. Does LL-BFR improve dynamic stability better than sham LL-BFRt and HL-Et?
3. Does LL-BFR prevent ACL injury better than sham LL-BFRt and HL-Et?

Participants will be randomized into three intervention groups: LL-BFRt, sham LL-BFRt, and HL-Et. Participants will be asked to do:

• In LL-BFRt, participants will be asked to do LL eccentric training (including double leg squats, split squats, deadlifts, and monster walks) with a 30% of repetition maximum (RM) and 70% of arterial occlusion pressure (AOP).
• In sham LL-BFRt, participants will be asked to do LL eccentric training with a 30% of repetition maximum (RM) and 10% of arterial occlusion pressure (AOP).
• In HL-Et, participants will be asked to do LL eccentric training with a 70% of repetition maximum (RM).

Researchers will compare LL-BFRt, sham LL-BFRt, and HL-Et to see if muscle strength, dynamic stability, and ACL injury prevention improve after the interventions and follow-up.

Full description

Participants will be asked to do five sets of ten repetitions of each eccentric training, one-minute rest interval for each eccentric training and two mins rest interval between each set.

Enrollment: 60 estimated patients

Sex: All

Ages: 15 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being 15-35 years old
• Perform sports level 1 (soccer, basket ball, futsal, combat martial art) at least twice per week.
• Never had an history of ACL injury
• Never had an history of sprain or strain grade III
• Agree to participate until the end of this study period and sign the inform consent

Exclusion criteria

• Having hypertension, blood circulation disease, anemia, obesity, diabetes, kidney failure, vena thromboembolic, cancer, and tumor.
• Disabilities or disabled people.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

60 participants in 3 patient groups

LL-BFRt

Experimental group

Description:

30% of repetition maximum and 70% of arterial occlusion pressure

Treatment:

Procedure: Low-load Blood Flow Restriction training

Sham LL-BFRt

Sham Comparator group

Description:

30% of repetition maximum and 10% of arterial occlusion pressure

Treatment:

Procedure: Sham Low-load Blood Flow Restriction training

HL-Et

Active Comparator group

Description:

70% of repetition maximum

Treatment:

Procedure: High-load Eccentric training