Effect of Blueberries on Immunity (Blueberry)

Loma Linda University (LLU)

Status: Completed

Conditions: Immune Response; Inflammation

Treatments: Dietary Supplement: Placebo powder group; Dietary Supplement: Blueberry powder group

Study type: Interventional

Funder types: Other

Identifiers

NCT05534893

5220098

Details and patient eligibility

About

This research study will test the effects of Blueberries on immune functions in overweight older men and postmenopausal women

Full description

This study will examine the effects of Blueberries on clinically relevant markers of immune function. Eligible and selected participants will be randomized to one of two groups at the baseline clinic visit. The Blueberry group participants will consume blueberries (2 packets of blueberry freeze-dried powder equivalent to 2 cups of fresh blueberries) added to the habitual diet and the Control group participants will abstain from blueberries (with instructions to limit the consumption of other berries and polyphenol rich foods) but otherwise continue their habitual diet. During the study, clinic visits will occur at 4-week intervals (baseline, weeks 4, 8 and 12) for a total of 4 visits at the Loma Linda University Nutrition Research Center. Blood samples taken at baseline and at week 12 will be assayed for changes in immune function and inflammatory markers.

Enrollment: 52 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Older men and post-menopausal women aged 50-70 year
2. Have BMI of 25-32
3. Able to commute to Loma Linda University
4. Consuming a typical American Diet low in polyphenols

Exclusion criteria

1. Intolerance or allergy to Blueberries
2. Regular intake of Blueberries and other berried (>2 ounces/week)
3. Immune system insufficiency or disease
4. Using immune boosting supplements
5. Exposure to antibiotics and corticoids immediately prior to study
6. Uncontrolled chronic diseases and relevant psychiatric illness, including major depression
7. Flu vaccination and or Covid Vaccination less than 3 months ago from the start of the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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52 participants in 2 patient groups, including a placebo group

Blueberry powder group

Experimental group

Description:

Participants in the blueberry powder group will receive freeze dried blueberries in form of a powder

Treatment:

Dietary Supplement: Blueberry powder group

Dietary Supplement: Placebo powder group

Placebo powder group

Placebo Comparator group

Description:

Participants in the placebo group will receive an isocaloric placebo powder.

Treatment:

Dietary Supplement: Blueberry powder group

Dietary Supplement: Placebo powder group