Effect of Botulinum Toxin a Injection in Treatment of Recession RT1 and RT2

Cairo University (CU)

Status: Not yet enrolling

Conditions: Gingival Recession

Treatments: Procedure: Botulinum toxin-A injection; Procedure: Coronally advanced flap

Study type: Interventional

Funder types: Other

Identifiers

NCT06842290

PER3,3,2

Details and patient eligibility

About

The goal of this study type: clinical trial] is to learn the effect of Botulinum Toxin _A injection in treatment of RT1andRT2 Gingival recession in lower anterior teeth .

Primary outcome is keratinzed tissue width. Researchers will compare Coronally Advanced flap with De-epithelized free gingival graft and Botulinum toxin-A injection in Mentalis muscle with coronally advanced flap with De-epithelized free gingival graft alone .

The outcome will be measured at baseline, after 3 months and after 6 mobths _medical history

• 3 mm horizontal incisions, then two vertical incisions
• deepitheliztion of anatomical papillae
• superficial and deep incisions
• harvesting DFGG
• Suturing
• BOTOX injection

Enrollment: 28 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Single or multiple RT1, RT2 GR patient
• patients ≥18 years
• systemically healthy, full mouth plaque score, full mouth bleeding score ≤ 15% after phase I therapy
• clinical indication and/or patient request for recession coverage
• well motivated patients, maintaining oral hygiene throughout study

Exclusion criteria

• Pregnant or lactating women
• Smokers' patients
• Teeth with cervical restorations/abrasion.
• Patients had a systemic condition affect blood components and healing

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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28 participants in 2 patient groups

Intervention arm

Experimental group

Description:

In this arm principal investigator will preform coronally advanced flap with De-epithelized free gingival graft then will inject Botulinum toxin-A in Mentalis muscle after suturing

Treatment:

Procedure: Botulinum toxin-A injection

Control arm

Active Comparator group

Description:

In this arm no injection will be applied only coronally advanced flap with De-epithelized free gingival graft alone

Treatment:

Procedure: Coronally advanced flap