Effect of Brazilian Fruits Peel on Metabolic Regulation and Appetite in Healthy Subjects (BRASIL-MET)

Lund University

Status and phase: Completed; Phase 2; Phase 1

Conditions: Healthy

Treatments: Dietary Supplement: Brazilian fruit peel flour; Dietary Supplement: Negative control drink; Dietary Supplement: Control drink

Study type: Interventional

Funder types: Other

Identifiers

NCT02245906

BRASIL-MET

Details and patient eligibility

About

The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective appetite ratings (VAS-visual analogue scales) in healthy volunteers. We hypothesize that certain Brazilian fruits peel added to a standardized meal will improve postprandial glucose tolerance and other metabolic biomarkers in healthy volunteers, compared with a similar meal without the corresponding plant materials.

Enrollment: 17 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy males and females
• Signed informed consent
• BMI 20 - 28 kg/m2 with weight change <3 kg latest 2 months
• Must be able to accept plant-based foods/drinks

Exclusion criteria

• Below 18 years
• Uncomfortable speaking English and/or difficulties in understanding spoken English
• Smoking or using snuff
• Vegetarian or vegan
• Stressed by venous blood sampling or previous experience of being difficult to cannulate
• Receiving any drug treatment that may influence the study outcomes
• Pregnancy or breastfeeding

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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17 participants in 3 patient groups, including a placebo group

Control drink

Placebo Comparator group

Description:

300 ml control drink containing equal amount of total fiber and pectine as Brazilian fruit drink, acute study / one time administration

Treatment:

Dietary Supplement: Control drink

Brazilian fruit peel

Experimental group

Description:

300 ml test drink containing Brazilian fruit peel flour, acute study / one time administration

Treatment:

Dietary Supplement: Brazilian fruit peel flour

Negative control drink

Placebo Comparator group

Description:

300 ml control drink without containing amount of total fiber and pectine as Brazilian fruit drink, acute study / one time administration

Treatment:

Dietary Supplement: Negative control drink