Effect of Butorphanol on Colonoscopy for Patients With Postoperative Visceral Pain

Capital Medical University

Status and phase: Completed; Phase 4

Conditions: Colonoscopy

Treatments: Drug: Saline; Drug: Butorphanol Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT04477733

wj20200710

Details and patient eligibility

About

The total incidence of abdominal pain after colonoscopy is almost 50%. Butorphanol is a mixed opioid receptor agonist-antagonist, which has strong sedative and analgesic effects. This clinical study aims to explore the effectiveness and safety of butorphanol combined with propofol for colonoscopy to reduce postoperative visceral pain, and provide a basis for improving the quality of surgery and comfortable medical treatment for patients.

Enrollment: 203 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA status I-11
• patients performing colonoscopy
• sign the informed consent

Exclusion criteria

• BMI>30, pregnant
• diabetes
• depression
• patients dependent on opioids
• hypertension poorly controlled
• serious complications of important organs
• obvious abdominal pain before colonoscopy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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203 participants in 2 patient groups, including a placebo group

Butorphanol group

Experimental group

Treatment:

Drug: Butorphanol Injection

control group

Placebo Comparator group

Treatment:

Drug: Saline