Effect of Ca2+ Ionophore on Embryonic Development and Clinical Outcome in Cases With Previous Fertilization Arrest

T

TopLab Company for ART Laboratories Consultation and Training

Status

Unknown

Conditions

Fertilization Arrest

Treatments

Other: Ca2+ ionophore

Study type

Interventional

Funder types

Other

Identifiers

NCT02683031
#0010010

Details and patient eligibility

About

We aimed to investigate the efficiency of chemical oocyte activation using readymade Ca2+ ionophore on cases with previously cancelled cases due to fertilization arrest at pronuclear stage i.e: cleavage failure to find out if there is any improvement in embryonic developmental stages.

Full description

Many studies reported that Ca2+ ionophore has a positive effect on embryo development in cases with complete or partial fertilization failure. However, only one preliminary report suggested a beneficial effect of Ca2+ ionophore activation in four cases with fertilization arrest.

Enrollment

50 estimated patients

Sex

Female

Ages

20 to 39 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with previous history of complete fertilization arrest.
  • ovarian stimulation with the GnRH agonist and recombinant FSH in a long protocol.

Exclusion criteria

  • Female age >40 years

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

50 participants in 2 patient groups

Without Ca2+ ionophore
No Intervention group
Description:
Patients with previous incomplete ICSI cycle due to fertilization arrest were counseled to underwent a subsequent conventional ICSI cycle.
With Ca2+ ionophore
Experimental group
Description:
Patients with previous incomplete ICSI cycle due to fertilization arrest were counseled to underwent a subsequent ICSI cycle combined with artificial oocyte activation using Ca2+ ionophore.
Treatment:
Other: Ca2+ ionophore

Trial contacts and locations

1

Loading...

Central trial contact

Yasmin Magdi, M.Sc; Ahmed El-Damen, M.Sc

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems