Effect of Caffeine on Heart Function

The University of Texas System (UT)

Status: Completed

Conditions: Tachycardia; Fatigue

Treatments: Dietary Supplement: Monster Energy Drink; Dietary Supplement: Coffee; Dietary Supplement: Monster energy drink

Study type: Interventional

Funder types: Other

Identifiers

NCT02401776

2014-03-0069

Details and patient eligibility

About

• The primary objective of this study is to assess the effect of an energy drink on ventricular repolarization as measured by the interval between the cardiac Q wave and the cardiac T wave (QT interval)obtained from the body surface ECG.
• The secondary objective is to assess the effects of an energy drink on heart rate and blood pressure (hemodynamic effects).

To place the observed changes in context, comparison will be made to a commonly consumed drink, coffee: Starbuck's K-cup Breakfast Blend.

Full description

This study will assess cardiac repolarization before and after three conditions each of which will involve the subject drinking beverages of varying caffeine content.

Enrollment: 30 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• BMI between 24 - 29

Exclusion criteria

• Resting heart rate below 60 bpm
• Resting heart rate above 88 bpm
• Cardiovascular or metabolic disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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30 participants in 3 patient groups

small dose monster energy drink

Experimental group

Description:

This will be a small dose of monster energy drink

Treatment:

Dietary Supplement: Monster Energy Drink

Dietary Supplement: Coffee

Dietary Supplement: Monster Energy Drink

medium dose monster energy drink

Experimental group

Description:

This will be a medium dose of monster energy drink

Treatment:

Dietary Supplement: Monster Energy Drink

Dietary Supplement: Coffee

Dietary Supplement: Monster Energy Drink

coffee

Active Comparator group

Description:

This will be a coffee group and will drink Starbuck's K-cup Breakfast Blend. This will be mixed according to packing instructions and will be given at a dose of 2mg caffeine/kg body weight (equivalent to approximately one 11 ounce cup of coffee for a person weighing 75 kg).

Treatment:

Dietary Supplement: Monster Energy Drink

Dietary Supplement: Coffee

Dietary Supplement: Monster Energy Drink