Effect of Caffeine on Preterm Infants' Bone Mineral Content

Ain Shams University

Status: Completed

Conditions: Apnea of Prematurity; Osteopenia (Disorder)

Treatments: Diagnostic Test: Dual Energy X-ray Absorptiometry

Study type: Observational

Funder types: Other

Identifiers

NCT03084432

16246

Details and patient eligibility

About

The primary objective was to determine whether caffeine therapy is associated with decreases bone mineral content using dual energy x-ray absorptiometry. Secondary objectives were to determine whether caffeine therapy is associated with increased incidence of nephrocalcinosis or bone fracture.

Enrollment: 42 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Preterm infants with gestational age of 34 weeks or less consecutively admitted to the neonatal intensive care unit

Exclusion criteria

Renal or endocrinal diseases Congenital anomalies Suspected chromosomal aberrations Receiving diuretics or steroid therapy

Trial design

42 participants in 2 patient groups

caffeine group

Description:

22 preterm infants received caffeine (starting from day 2 of life and received for more than 7 days) for apnea prophylaxis or treatment according to protocol of Ain Shams University neonatal intensive care unit \[apnea prophylaxis for preterm ≤32 weeks gestation and apnea treatment for those 33 or 34 weeks gestation\]. Dual Energy X-ray Absorptiometry was done 5th-6th week post-natal age

Treatment:

Diagnostic Test: Dual Energy X-ray Absorptiometry

control group

Description:

20 preterm infants for whom caffeine was not given, either it was not indicated, not available or parents refused its use.Dual Energy X-ray Absorptiometry was done 5th-6th week post-natal age

Treatment:

Diagnostic Test: Dual Energy X-ray Absorptiometry