Effect of Caffeine on Time to Anesthetic Emergence After Laparoscopic Cholecystectomy : Randomized-controlled Trial

Tunis University

Status and phase: Unknown; Phase 2

Conditions: Laparoscopic Cholecystectomy

Treatments: Drug: Placebo; Drug: 300 mg of caffeine citrate infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT05079880

HTHEC-2017-09

Details and patient eligibility

About

A faster emergence from general anesthesia has a double medico-economic impact by reducing the risks of complications and optimizing the performance of surgical units. No drug has been retained for its ability to actively accelerate anesthetic emergence by antagonizing hypnotics. Thus, the aim of this study was to examine the effect of caffeine on the time to emerge from sevoflurane anesthesia for laparoscopic cholecystectomy.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American society of Anesthesiologists (ASA) I and II patients, aged older than 18 years old and scheduled for laparoscopic cholecystectomy

Exclusion criteria

• Patient with an allergy to caffeine citrate and analgesics used during postoperative period, those with severe renal or hepatic failure, those who refused to participate in addition to patient with heart rhythm disorder, seizure disorder, hypertension, alcoholic or psychiatric illness

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

GC group

Experimental group

Description:

received 300 mg of caffeine citrate infusion

Treatment:

Drug: 300 mg of caffeine citrate infusion

GS group

Placebo Comparator group

Description:

Equivalent saline infusion

Treatment:

Drug: Placebo