Effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain and Bacterial Reduction in Mandibular Premolars With Necrotic Pulps. .

Cairo University (CU)

Status: Not yet enrolling

Conditions: Intervention

Treatments: Other: Calcium Hypochlorite as Root Canal Irrigant

Study type: Interventional

Funder types: Other

Identifiers

NCT06509295

ENDO 3-7-1(10/4/2024)

Details and patient eligibility

About

This study aims to assess the effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain and Bacterial Reduction in Mandibular Premolars with Necrotic Pulps.

Enrollment: 30 estimated patients

Sex: All

Ages: 20 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Systematically healthy patient (ASA I, II).
2. Age between 20 and 55 years
3. Male or female.
4. Mandibular premolar teeth having single canals diagnosed with pulp necrosis with asymptomatic apical periodontitis.
5. Radiographic examination using Digora intraoral periapical sensor plate and software showing mandibular premolars with (0-2 mm) periapical radiolucency.

Exclusion criteria

1. Medically compromised patients having significant systemic disorders. (ASA III or IV).

2. History of intolerance to NSAIDS.

3. Teeth with:

   • Immature roots
   • Vital pulp tissues.
   • Association with swelling.
   • Acute peri-apical abscess or acute exacerbation of a chronic abscess.
   • Mobility Grade II or III.
   • Previously accessed or endodontically treated
   • Deep periodontal pockets more than 4 mm
   • Vertical root fractures, coronal perforation, calcification, and external or internal root resorptions.

4. Patients who could not interpret the NRS.

5. Patients with diabetes, immune-compromising, and immunosuppression disease and pregnant women were, also, excluded.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

30 participants in 2 patient groups, including a placebo group

Calcium Hypochlorite as root canal Irrigant on Postoperative Pain and bacterial load reduction

Placebo Comparator group

Description:

Treatment with Calcium Hypochlorite as root canal Irrigant

Treatment:

Other: Calcium Hypochlorite as Root Canal Irrigant

Sodium Hypochlorite as a root Canal Irrigant

Active Comparator group

Description:

Treatment with Sodium Hypochlorite as root canal Irrigant

Treatment:

Other: Calcium Hypochlorite as Root Canal Irrigant