Effect of Cannabidiol (CBD) on Vision and Driving

University of Granada (UGR)

Status and phase: Active, not recruiting; Early Phase 1

Conditions: Cannabis Use

Treatments: Other: CBD 15%; Other: CBD 30%; Other: Placebo (CBD 0%)

Study type: Interventional

Funder types: Other

Identifiers

NCT06322303

C-EXP-194-UGR23

Details and patient eligibility

About

The use of cannabis with ∆9-tetrahydrocannabinol (THC) content has been shown to have negative effects on vision and driving. The use of other cannabinoids, such as cannabidiol (CBD), which is not attributed with a psychoactive effect, is increasing significantly. This project aims to investigate whether consuming CBD can negatively affect visual function by assessing a wide range of visual parameters and whether these changes may pose a risk for everyday activities such as driving.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 43 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being an occasional cannabis and/or cannabidiol user
• Have a current driving licence
• Have at least one year's driving experience
• Drive at least once a week
• Monocular visual acuity of at least 6/6 (Snellen) with habitual correction for driving
• Absence of binocular disorders

Exclusion criteria

• Certain past or present medical conditions
• Current cannabis or alcohol use disorder
• Use of other drugs
• Pregnancy or lactation
• Simulator sickness.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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60 participants in 3 patient groups, including a placebo group

Placebo (CBD 0%)

Placebo Comparator group

Description:

Participants are required to vaporize a placebo at 0% CBD concentration

Treatment:

Other: Placebo (CBD 0%)

CBD 15%

Experimental group

Description:

Participants are required to vaporize CBD at a concentration of 15%.

Treatment:

Other: CBD 15%

CBD 30%

Experimental group

Description:

Participants are required to vaporize CBD at a concentration of 30%.

Treatment:

Other: CBD 30%