Effect of Captopril on GLS in Duchenne Myodystrophy

Ain Shams University

Status and phase: Enrolling; Early Phase 1

Conditions: Effect of Drug

Treatments: Drug: Captopril Tablets

Study type: Interventional

Funder types: Other

Identifiers

NCT06485661

MS180/2024

Details and patient eligibility

About

To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD)

Full description

ACEI slowing down the onset and the progression of dystrophinopathic cardiomyopathy.

To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD

Enrollment: 20 estimated patients

Sex: Male

Ages: 6+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Genetically confirmed Duchenne myodystrophy (DMD) patients with abnormal GLS < -18% with minimum age of 6 years old.

Exclusion criteria

• Any patient who refuses to sign an informed consent.
• Contraindication to ACEI: hypersensitivity - renal impairment - bilateral renal artery stenosis - aortic valve stenosis - hyperkalemia - hypotension.
• Reduced ejection fraction below 50%.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Duchenne patients subjected to captopril

Other group

Treatment:

Drug: Captopril Tablets