Effect of Carbonated Soft Drinks on Appetite-Regulation

Aarhus University Hospital

Status: Completed

Conditions: Obesity; Diet

Treatments: Other: Sugar-sweetened soft drink; Other: Aspartame-sweetened soft drink; Other: Semi-skimmed milk; Other: Water

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00776971

20070134A

Details and patient eligibility

About

Compared to solid foods, the nutritional energy of drinks may bypass the appetite regulation leading to obesity development. Although drinks sweetened with aspartame are available the anticipated positive effect of these drinks on obesity development has not been convincing. However, the mechanisms linking drinks intake to obesity are yet to be clarified.

The investigators aim is to investigate the short-term effects of soft drinks (sugar-sweetened and artificially sweetened (aspartame)), milk and water on the concentration of circulating appetite-regulating hormones, the subjective sensations of hunger and satiety (measured by visual analogue scales) and energy intake. The study is a crossover, intervention trial with 24 overweight, healthy volunteers. The subjects will be tested on four separate days for four hours. Each test day a preload drink (sugar-sweetened soft drink, aspartame-sweetened soft drink, semi-skimmed milk or water) is served.

The investigators expect to clarify the mechanisms linking drinking habits to obesity development and provide scientifically based nutritional guidelines.

Enrollment: 24 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 20-50 years;
• BMI between 28-36 kg/m2;
• Weight stabile 3 months prior to the study inclusion;
• Less than 10 hours of weekly exercise.

Exclusion criteria

• Diabetes
• Allergic to phenylalanine or milk
• Smoking
• Pregnancy or breast-feeding

Trial design

24 participants in 4 patient groups, including a placebo group

Sugar-sweetened soft drink

Experimental group

Description:

54g sugar/L, 180kJ/100mL

Treatment:

Other: Sugar-sweetened soft drink

Aspartame-sweetened soft drink

Experimental group

Description:

1.5kJ/100mL

Treatment:

Other: Aspartame-sweetened soft drink

Semi-skimmed milk

Active Comparator group

Description:

202kJ/100mL

Treatment:

Other: Semi-skimmed milk

Water

Placebo Comparator group

Description:

0kJ/100mL

Treatment:

Other: Water