Effect of Cardiac Preconditioning Upon the Inotrope Score

Assiut University

Status: Completed

Conditions: Open Heart Surgery; Preconditioning

Treatments: Procedure: ischemic preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT03105089

IRB00009910

Details and patient eligibility

About

preconditioning of no debate has a valuable effect upon myocardial protection . pre-cardiopulmonary bypass pre-conditioning , suspected to have a role upon postoperative inotropic support

Full description

Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be ( ischemic ;pharmacologic or Physical) Pharmacological pc may be induced by variable agents e.g. (Sevoflurane ;isoflorane, opioids etc ) Ischemic pc includes local ;remote and the idea is temporary interruption of blood supply to the organ so that liberation of protective mediators occurs The liberated mediators have favorable effects not only upon the myocardium But ;it extend to protect other organs against inflammatory activation ;ischemia reperfusion injury Inotropic score IS is already an evident predictor of postoperative cardiac mobidity and mortality

Enrollment: 60 patients

Sex: All

Ages: 16 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patient
• valve replacement surgery
• ASA grade 2 or 3

Exclusion criteria

• emergency surgery
• • poor general conditions
• impaired hepatic or renal function
• peripheral vascular disease
• patient refusal

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

ischemic preconditioning

Active Comparator group

Description:

ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles

Treatment:

Procedure: ischemic preconditioning

control

No Intervention group

Description:

no intervention will be done