Effect of Carum Carvi on Thyroid Hormones and TSH Level

Mashhad University of Medical Sciences

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Thyroid Cancer Patients

Treatments: Drug: Carum Cravi; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01471288

88498

Details and patient eligibility

About

Carum Carvi has been frequently used in traditional medicine for a variety of disease ranging from dyspepsia to Alzheimer's disease.We observed high TSH levels in few patients with thyroid cancer who receiving Carum Carvi despite being on suppressive dose of levothyroxin. TSH level returned to normal after discontinuation of the Carum carvi. This observation led to a pilot study for evaluation of the effect of carum carvi on thyroid function.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-65
• Hypothyroid patients under treatment with levothyroxin
• Normal euthyroid patients with no goiter

Exclusion criteria

• Pregnancy or lactation
• Severe lung or gasterointestinal disease
• Heart failure or renal failure

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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40 participants in 4 patient groups, including a placebo group

Group3

Active Comparator group

Description:

Normal controls

Treatment:

Drug: Carum Cravi

Group4

Placebo Comparator group

Description:

Normal controls

Treatment:

Drug: Placebo

Group 1

Active Comparator group

Description:

Hypothyroid patients taking levothyroxin.

Treatment:

Drug: Carum Cravi

Group2

Placebo Comparator group

Description:

Hypothyroid patients taking levothyroxin

Treatment:

Drug: Placebo