Effect Of Carvedilol Versus Metoprolol On Glycemic Control In Patients With Type II Diabetes And Hypertension

GlaxoSmithKline (GSK)

Status and phase: Completed; Phase 4

Conditions: Hypertension

Treatments: Drug: carvedilol; Drug: metoprolol

Study type: Interventional

Funder types: Industry

Identifiers

NCT00060931

105517/347

Details and patient eligibility

About

Evaluation of the effect of two different antihypertensive treatments on control of glucose in Type II diabetic patients with high blood pressure

Enrollment: 501 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients at screening must be insulin producing Type II diabetics (C peptide positive).
• Patients must have a history of mild to moderate hypertension (140-179 systolic blood pressure; 90-1-9 diastolic blood pressure)
• Patients must be on a stable regimen of ACE (angiotensin converting enzyme) / ARB (angiotensin receptor blocker) treatment alone or in combination with other treatments.
• Patients must be on stable antidiabetic regimen (drug treated or diet alone).
• Patient''s laboratory result for HbA1c must be 6.5 - 8.5 (drug treated) or 6.5 - 7.5 (diet alone).

Exclusion criteria

• Patients using beta-blocker therapy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind