Effect of Cavotricuspid Isthmus Ablation in Patients Without History of Typical Flutter During Ablation

Yong Seog Oh

Status: Completed

Conditions: Paroxysmal Atrial Fibrillation

Treatments: Procedure: cavotricuspid isthmus ablation; Procedure: control group

Study type: Interventional

Funder types: Other

Identifiers

NCT02031705

CTI (Other Grant/Funding Number)

Details and patient eligibility

About

It has been demonstrated that successful cavotricuspid isthmus ablation may be effective in preventing paroxysmal atrial fibrillation. However, the effectiveness of only isthmus ablation on atrial fibrillation itself is unclear.

Full description

Researchers hypothesized that an organized activation pattern around the tricuspid annulus during atrial fibrillation indicated a mother reentrant circuit that could be terminated by a cavocaval isthmus ablation, thus preventing atrial fibrillation. The objectives of the present study were to evaluate the effectiveness of isthmus ablation in preventing atrial fibrillation and to identify predictors of its success.

Enrollment: 366 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Scheduled ablation for paroxysmal atrial fibrillation

Exclusion criteria

• Typical atrial flutter
• History of artificial tricuspid valve surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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366 participants in 2 patient groups, including a placebo group

cavotricuspid isthmus ablation

Active Comparator group

Description:

Isthmus ablation was performed in paroxysmal atrial fibrillation patients.

Treatment:

Procedure: cavotricuspid isthmus ablation

control group

Placebo Comparator group

Description:

Control group was performed no additional cavotricuspid isthmus ablation.

Treatment:

Procedure: control group