Effect of Cefazolin and Normal Saline Irrigation on Surgical Site Infections (SSIs)

Hormozgan University of Medical Sciences

Status: Completed

Conditions: Surgical Site Infections

Treatments: Other: Cefazolin irrigation; Other: Normal Saline Irrigation

Study type: Interventional

Funder types: Other

Identifiers

NCT01566734

U1111-1128-4677

Details and patient eligibility

About

This study conducted to assess the effects of normal saline or cefazolin irrigation on the incidence of SSIs.

Hypothesis:

Normal saline or cefazolin irrigation decreases the incidence of SSIs.

Full description

All pregnant women who underwent cesarean after 6 hours passed their rupture of membrane and attended to Shariati Hospital of Bandarabbass were eligible for our study.

Enrollment: 200 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• pregnant women
• 6 hours passed their rupture of membrane
• needed to undergo cesarean

Exclusion criteria

• allergy to penicillin
• allergy to cefazolin
• history of immunosuppressive drug use
• gestational diabetes mellitus
• preeclampsia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

200 participants in 3 patient groups

Cefazolin

Experimental group

Description:

after the surgery and before closing up the patients, 2 grams of cefazolin in 5 cc of distilled water was used to irrigate the patients

Treatment:

Other: Cefazolin irrigation

Normal Saline

Experimental group

Description:

after the surgery and before closing up the patients, 150 cc of normal saline was used to irrigate the patients

Treatment:

Other: Normal Saline Irrigation

Control

No Intervention group