Effect of CGF on Postoperative Edema in Third Molar Surgery

Ege University

Status

Completed

Conditions

Oral Complication

Treatments

Other: Non-CGF

Other: Concentrated Growth Factor

Study type

Interventional

Funder types

Other

Identifiers

NCT06893523

EGE-DHF-MZ-001

Details and patient eligibility

About

The purpose of this study is to evaluate the effects of concentrated growth factor (CGF) on edema after bilateral impacted third molar surgery and to determine its contribution to the healing process.

The main question it aims to answer is:

Is CGF effective on reducing the edema in impacted third molar surgery? Researchers compare the edema amount on the CGF-applied and CGF free sides after impacted third molar surgery. The edema measurements are performed on the second and seventh days.

Full description

It has been observed that the treatment of impacted tooth extraction, which is the most commonly performed interventional procedure in oral and maxillofacial surgery clinics and affects the patient's comfort and daily life after the operation, has been investigated in many ways and new ideas are constantly emerging. Wound healing is a process controlled by many intracellular and extracellular mechanisms. In recent years, many studies have been conducted to make this process faster and more successful, and it has been observed that the use of platelet products in this area has yielded extremely successful results. Concentrated Growth Factor (CGF), which has gained an important place in regenerative medicine in recent years, has attracted attention due to its potential to minimize postoperative complications.

This randomized clinical trial was conducted at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ege University.

Forty-nine patients, regardless of gender, with bilateral, symmetrical, bone-retained (vertical, mesioangular, horizontal) impacted third molar in the mandible and without any systemic disease are included in the study. Before the impacted third molar surgery, detailed medical and dental history are taken from the patients.

The patients are informed in detail about the drugs to be used in the study, the applied method, the duration and purpose of the study.

In order to obtain the data required for statistical analysis of the amount of edema on the sides where CGF is used and not used after the operation, edema measurements are made at three points on the patients before the operation, on the 2nd and 7th days after the operation.

These measurements are made between the external canthus-angulus mandible, tragus-commissura and tragus-pogonium.

Wilcoxon Signed Ranks test is used to compare the means of two dependent samples and to determine the significance of the difference between them.

Enrollment

49 patients

Sex

All

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients with bilateral, symmetrical, bone-retained (vertical, mesioangular, horizontal) impacted wisdom teeth in the mandible, regardless of gender
Patients without any systemic disease
Patients who have been informed about the duration, purpose and requirements of the study and who have signed the informed consent form voluntarily.-

Exclusion criteria

Having a disease affecting general health that requires the application of prophylactic antimicrobial agents
Having a systemic viral, fungal or bacterial infection
Patients with acute or chronic maxillary sinusitis
Suspected or diagnosed pregnancy and nursing mothers
Patients with heart and vascular diseases
Patients with liver disease, haematological disease and neoplastic disease
Patients who have recently received anti-inflammatory therapy
Patients with chronic medication use (antihistamines, NSAIDs, steroids and antidepressants)
Patients predisposed to psychotic or psychopathic tendencies
Patients with rheumatic diseases, blood diseases, diabetes mellitus
Patients at cardiological risk of infective endocarditis
Patients under antibiotic pressure