Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

University of Exeter

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Cherry concentrate; Dietary Supplement: Placebo concentrate

Study type: Interventional

Funder types: Other

Identifiers

NCT03547102

115229/02

Details and patient eligibility

About

Effect of 8 weeks of cherry concentrate supplementation on cognitive function and brain perfusion in healthy older adults

Full description

The investigators will perform a double blind, randomised controlled study to determine whether cherry polyphenols improve peripheral vascular function and cerebral perfusion resulting in improved task related brain activation and cognitive function. 30 healthy elderly men and women 60-85y years will be recruited to complete 8-week supplementation with MC concentrate or an isoenergetic cherry placebo concentrate. Participants will be pair matched for age, sex, and cognitive function (Adenbrooke's Cognitive Examination III, ACE-III) and then randomised using a sealed envelope system to receive either placebo or cherry.

Enrollment: 30 patients

Sex: All

Ages: 60 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• physically inactive consuming 5 or less portions of fruit per day Addenbrookes cognitive examination III score >88

Exclusion criteria

• physically active consuming more than 5 portions of fruit per day Addenbrookes cognitive examination III score <88 Contraindications for MRI

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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30 participants in 2 patient groups, including a placebo group

Cherry concentrate

Active Comparator group

Description:

8 weeks supplementation with montmorency cherry concentrate

Treatment:

Dietary Supplement: Cherry concentrate

Placebo concentrate

Placebo Comparator group

Description:

8 weeks supplementation with placebo isoenergetic cherry concentrate

Treatment:

Dietary Supplement: Placebo concentrate