Effect of Chewing Gum in Hemodialysis Patients

Istanbul Demiroglu Bilim University

Status

Completed

Conditions

Hemodialysis

Chewing Gum

Treatments

Dietary Supplement: Chewing Gum

Study type

Interventional

Funder types

Other

Identifiers

NCT04142216

2019/7

Details and patient eligibility

About

The aim of this prospective randomized controlled study was to investigate the effects of chewing gum on interdialytic weight gain, thirst, dry mouth and intradialytic symptoms in hemodialysis patients.

Full description

The prevalence of xerostomia varies high in patients with chronic hemodialysis (HD), and the decreased saliva flow rate due to various mechanisms is the main factor in its development. The significant decrease in saliva flow due to the atrophy and fibrosis of the salivary glands in HD patients is further affected by the restriction in fluid intake. The use of drugs such as antidepressants, antipsychotics, antihistamines, antihypertensives, aspirin, benzodiazepines, opioids and proton pump inhibitors also leads to hyposalivation and xerostomia. Thirst is common in chronic HD patients due to both volumetric and osmometric causes but the primary mechanism is osmometric. The osmolarity of the extracellular fluid increases with the dietary salt and the hypothalamus is stimulated by the shrinkage of the osmoreceptor cells, leading to the desire to ingest liquids. Volumetric thirst develops secondary to water and salt loss and the resultant stimulation of cardiac baroreceptors, with the cardiac return volume decreasing gradually towards the end of the HD session. Increased interdialytic weight in HD patients causes increased risk of death due to cerebrovascular events and cardiovascular diseases and leads to an increase in morbidity and mortality together with a deterioration of the patient's quality of life. Interdialytic weight gain (IWG) causes incompliance with fluid control as a result of the secondary excessive consumption of liquid and food and is an important condition.

Enrollment

56 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

18 years of age or older
On maintenance hemodialysis three times per week for four hours per session
Receiving hemodialysis therapy for a least six moths at the time of the study
Able to communicate in Turkish
Willing to participate to the study

Exclusion criteria

18 years of age younger
Absence of psychiatric disorders that cause cognitive dysfunction, such as Alzheimer's disease or chronic psychosis.
The patient who took chemotherapy and radiotherapy
Have salivary gland infection and dementia
Oral and / or dental diseases to prevent chewing gum
Unwilling to to participate to the study