Effect of Childhood Radioiodine Therapy on Salivary Function

Boston Children's Hospital

Status: Completed

Conditions: Xerostomia; Hyperthyroidism; Thyroid Cancer

Treatments: Other: Radioiodine

Study type: Observational

Funder types: Other

Identifiers

NCT02375451

IRB-P00012399

Details and patient eligibility

About

Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease.

Full description

Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease. We will use a Modified Shirmer Test to measure saliva production and a questionnaire to evaluation symptoms of xerostomia.

Enrollment: 70 patients

Sex: All

Ages: 3 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who have been treated with radioiodine therapy
• Patients who have never received radioiodine therapy (negative control group)

Exclusion criteria

• Non-English speaking subjects will be excluded due to our lack of translation support resources at this time. Of note, participation in our study cannot benefit participants in any way.

Trial design

70 participants in 2 patient groups

Radioiodine

Description:

Patients with a history of childhood treatment with radioiodine will be assessed for symptoms of salivary function and measurement of saliva production. These data will be compared to a normal control group.

Treatment:

Other: Radioiodine

Control

Description:

Patients who are similar in age to those in the Radioiodine group, but who did not recieve I-131 therapy.