Effect of Chlorhexidine-Induced Oral Care on Ventilator-Related Some Respiratory System Complications

Karabuk University

Status: Completed

Conditions: Ventilator Associated Pneumonia; Tracheobronchitis

Treatments: Drug: 0.12% chlorhexidine gluconate; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT04505202

2091

Details and patient eligibility

About

Ventilator-associated pneumonia and ventilator-associated treakeabronchitis in respiratory tract infections associated with ventilator are common infections in intensive care unit and cause significant morbidity, mortality and health expenditures in nosocomial infections. Adequate and effective oral care by nurses in intensive care patients, possible complications, intensive care unit stay in the intensive care unit and is very important in terms of mortality.

Full description

The aim of this study will (1) evaluate the effect of 0.12% chlorhexidine gluconate on ventilator-associated pneumonia, ventilator-associated treakeabronchitis, (2) determine the effect of preventing microorganism colonization, and (3) assess the mortality rate for each patient and the cost-effectiveness in the health expenditures.

Enrollment: 57 patients

Sex: All

Ages: 18 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Admission in critical care with in 24 hours
• Having an endotracheal tube

Exclusion criteria

• History of chlorhexidine allergy
• Duration of mechanichal ventilation less than 48 h
• Confirmed diagnosis of pneumonitis before admission in the ICU
• Transfer from another ICU
• Receiving chemotherapy or radiotherapy
• Patients with immunodeficiency
• Patients with tracheostomies
• Required specific oral hygiene procedures
• Facio-maxillary or dental trauma/surgery
• Being pregnant

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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57 participants in 2 patient groups, including a placebo group

Experimental group

Experimental group

Description:

0.12% chlorhexidine gluconate

Treatment:

Drug: 0.12% chlorhexidine gluconate

Placebo group

Placebo Comparator group

Description:

sodium bicarbonate

Treatment:

Drug: Placebo