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Effect of Chronic Arsenic Exposure on Malnutrition of Under Five Children

A

Assiut University

Status

Unknown

Conditions

Malnutrition, Child
Arsenic Poisoning Chronic

Treatments

Diagnostic Test: arsenic exposure

Study type

Observational

Funder types

Other

Identifiers

NCT03893721
17100702

Details and patient eligibility

About

Early life malnutrition is associated with later life health problems, Particularly Stunting, which is a height-for-age Z score less than -2 standard deviation of World Health Organization median.Underweight is weight-for-age Z score less than -2 standard deviation of World Health Organization median. Wasting is weight -for- height Z score less than -2 standard deviation of World Health Organization median.

Full description

prevalence of under-five stunting, wasting and underweight are 21% and , 8% and 6% respectively in Egyptian Demographic Health Survey 2014.

The main risk factors for growth restriction in children are maternal under nutrition during pregnancy, lack of exclusive breastfeeding, inappropriate complementary feeding and micronutrient intake and high prevalence of enteric infections. However, other environmental exposures may also play a role in growth restriction .

High concentrations of Arsenic, lead and cadmium in placenta are associated with poor fetal out come and low birth weight. Arsenic crosses the placenta causing suppression of insulin-Like Growth Factor 1.

When breastfeeding is exclusive, infants are unlikely to be exposed to Arsenic by other routes of exposure such as external foods, drinking water and foods made at home using Arsenic contaminated water.

Rational of the study. Improvement of under-five nutritional status is a global target. Although the exposure to arsenic has increased globally, it's impact on nutritional status has seldom been investigated.

Enrollment

80 estimated patients

Sex

Female

Ages

2 to 5 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

female children from 2 to 5 years

Exclusion criteria

Severely ill children other than severely malnourished.

  • Children with congenital anomaly.
  • Relatives.

Trial design

80 participants in 2 patient groups

malnourished under five children
Description:
children from 2 to 5 years with malnutrition
Treatment:
Diagnostic Test: arsenic exposure
well nourished under five children
Description:
children from 2 to 5 years without malnutrition
Treatment:
Diagnostic Test: arsenic exposure

Trial contacts and locations

1

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Central trial contact

Eman Morsy, professor; Medhat Araby, assis. prof.

Data sourced from clinicaltrials.gov

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