Effect of Ciprofol Injection on Postoperative Cognitive Function

Chongqing Medical University

Status and phase: Active, not recruiting; Phase 4

Conditions: Postoperative Cognitive Dysfunction

Treatments: Drug: Propofol group; Drug: Ciprofol group

Study type: Interventional

Funder types: Other

Identifiers

NCT07673978

2026-166

Details and patient eligibility

About

This study aims to explore the effect of ciprofol on the postoperative cognitive function of inpatients undergoing gastrointestinal endoscopy examination, to compare the anesthetic effects and differences in adverse reactions of propofol and ciprofol in gastrointestinal endoscopy , to compare the incidence of postoperative cognitive decline in patients undergoing gastrointestinal endoscopy examination between propofol and coprofol, and to optimize the anesthesia medication regimen for patients undergoing gastrointestinal endoscopy examination.

Enrollment: 298 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age: 18-65 years old, ASA grade I-Ⅲ, BMI index: 18.5-30 kg/m ²
2. Patients who plan to undergo gastroscopy or colonoscopy in our hospital
3. The preoperative assessment of the MOCA scale in patients scheduled for elective surgery indicated normal cognitive function
4. dextromanuality
5. Voluntarily participate in this study and sign the informed consent form

Exclusion criteria

1. Pregnant or lactating women
2. Patients who have had cardiovascular and cerebrovascular accidents in the past
3. Patients with severe diseases of the cardiovascular system, respiratory system and liver and kidney system
4. Patients with obstructive sleep apnea syndrome
5. Patients with concurrent neurological or mental system diseases, or those with incomplete intellectual development
6. Patients allergic to ciprofol or propofol drugs
7. Patients with braking, visual/auditory impairments
8. Patients with psychotropic drug addiction or alcohol dependence
9. Patients who themselves or their attending physicians refused to participate in the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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298 participants in 2 patient groups

Experimental group (ciprofol)

Experimental group

Description:

patients in the Ciprofol group will use ciprofol to complete the painless gastroscopy and colonoscopy treatment.

Treatment:

Drug: Ciprofol group

Control group (propofol)

Active Comparator group

Description:

patients in the propofol group will use propofol to complete the painless gastroscopy and colonoscopy treatment.

Treatment:

Drug: Propofol group