Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia

Isfahan University of Medical Sciences

Status and phase: Completed; Phase 2

Conditions: Intraocular Pressure

Treatments: Drug: cisatracurium; Drug: atracurium

Study type: Interventional

Funder types: Other

Identifiers

NCT01273831

ASD-1213-10

Details and patient eligibility

About

The purpose of this study is to determine which drug makes lower intraocular pressure

Full description

Increase in intraocular pressure (IOP) following tracheal intubation during general anesthesia can be troublesome. The investigators compared the influence of cisatracurium and atracurium on IOP in patients undergoing general anesthesia.

Enrollment: 90 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

ASA class of I or II baseline IOP of lower than 20 mmHg stable hemodynamics no history of ophthalmic diseases not using drugs affecting IOP (e.g. anticholinergics, sympathomimetics) no contraindication for atracurium or cisatracurium administration.

Exclusion criteria

difficulty in mask ventilation or in tracheal intubation end expiratory CO2 of below 35 mmHg or over 45 mmHg O2 saturation of below 90%

Trial design

90 participants in 2 patient groups

atracurium

Other group

Description:

Patients who underwent general anesthesia received atracurium

Treatment:

Drug: atracurium

cisatracurium

Other group

Description:

Patients who underwent general anesthesia received cisatracurium

Treatment:

Drug: cisatracurium