Effect of Citric Acid Demineralization on Autogenous Bone Blocks Consolidation in Humans

University of Sao Paulo

Status: Completed

Conditions: Alveolar Bone Atrophy; Bone Resorption

Treatments: Procedure: Acid; Procedure: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT03357068

FOBblock

Details and patient eligibility

About

This study evaluates the effect of citric acid demineralization in autogenous bone blocks consolidation. Half of participants will receive citric acid treatment at the bone block and recipient site. Other half will receive no demineralization treatment.

Full description

Autogenous bone grafts are indicated in areas where there is not enough bone height and/or width for implant installation. Treatment of bone surfaces with citric acid, promote a slight demineralization on surface that mimic natural processes of bone demineralization by osteoclasts. Thus, this treatment could accelerate the process of autogenous bone block consolidation to its recipient site.

Enrollment: 10 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Presence of atrophic anterior maxilla (width 1.5 to 4 mm)
• Absence of active periodontal disease.
• Enough bone width on donor sites (oblique line or ment)

Exclusion criteria

• Systemic disease that impede surgical procedure as blood diseases, endocrine diseases, impaired coagulation
• Smokers
• Pregnant women
• Patients receiving radiotherapy or chemotherapy
• Patients using bisphosphonates

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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10 participants in 2 patient groups

Control

Active Comparator group

Description:

Autogenous bone block surgery without treatment of bone surfaces.

Treatment:

Procedure: Control

Acid

Experimental group

Description:

Autogenous bone block surgery with citric acid treatment of bone block and recipient site

Treatment:

Procedure: Acid