Effect of Citrulline Malate Supplementation on Physical Function and Biochemical Parameters in Physically Active Older Women

Universidad de Burgos

Status

Completed

Conditions

Supplementation

Treatments

Other: Multicomponent physical exercise programme

Study type

Interventional

Funder types

Other

Identifiers

NCT07143305

CITMAL

Details and patient eligibility

About

A randomised, double-blind, placebo-controlled pilot trial was conducted with thirty-three community-dwelling women aged 65 years or over. Participants were assigned to a multicomponent training programme (three days per week) and received either 3 g per day of citrulline malate or a placebo. Assessments were conducted before and after the intervention, including tests of physical performance (6MWT, sit-to-stand, SPPB), blood biomarkers (vitamin D, glucose, CK, hormones), and perceived quality of life (WHOQOL-BREF).

Enrollment

20 patients

Sex

Female

Ages

60 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Each participant underwent a comprehensive medical evaluation by their primary care physician to confirm their health status and eligibility.

Inclusion criteria:

Sex: women.
Age: 60-75 years.

Exclusion criteria:

Functional limitations (Barthel Index <100 and/or Lawton-Brody Scale <8).
Musculoskeletal injuries within the past six months.
Cardiovascular disease (e.g. advanced heart failure, unstable angina, recent myocardial infarction, arrhythmias, uncontrolled hypertension or hypotension, aortic stenosis, thromboembolic events).
Respiratory disorders (e.g. chronic respiratory failure or a moderate/severe BODEx index).
Endocrine/metabolic diseases (e.g. uncontrolled diabetes).
Neurological or psychiatric disorders (e.g. dementia).
Prior use of ergogenic nutritional supplements.
Any other condition deemed incompatible with moderate physical activity by the clinical team.