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Effect of Closed Tracheal Aspiration Associated With Expiratory Pause in Pediatrics Randomized, Crossover Clinical Study (expirapause)

H

Hospital Israelita Albert Einstein

Status

Unknown

Conditions

Respiratory Insufficiency in Children

Treatments

Other: without pause-with pause
Other: with pause- without pause

Study type

Interventional

Funder types

Other

Identifiers

NCT05418530
expiratory pause_2022

Details and patient eligibility

About

Introduction: Patients on mechanical ventilation suffer alterations in the viscoelastic characteristics of the mucus due to changes in the humidity and temperature of the inhaled air and in the respiratory volumes and flows. The literature has pointed out the use of mechanical ventilators as a tool for mobilizing secretions and closed-system aspiration associated with expiratory pause has been shown to be effective in mobilizing secretions. Objectives: To assess whether there is a difference in the mass of aspirated secretion with the application of the expiratory pause during aspiration. Methods: A crossover, randomized study. Applied to children aged 0 to 5 years and 11 months who are intubated for 24 hours with orotracheal tubes or tracheostomy. There will be an exclusion of patients who present with undrained pneumothorax, cranial hypertension or any other clinical situation that has a clinical contraindication to aspiration and patients whose parents do not agree to participate in the study. The technique will be during aspiration in the tube with where to apply or not the expiratory pause on the mechanical ventilator. This secretion will be weighed so that there is fidelity in the results.

Full description

A prospective, crossover, randomized clinical study will be carried out in the Pediatric ICU of Hospital Israelite Albert Einstein.

Enrollment

40 estimated patients

Sex

All

Ages

Under 5 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients aged 0 to 5 years and 11 months who have been on invasive mechanical ventilation for more than 24 hours through an orotracheal cannula or tracheostomy will be included in the study.

Exclusion criteria

  • Patients who present with undrained pneumothorax, cranial hypertension or any other clinical situation that has a clinical contraindication to aspiration and patients whose parents do not agree to participate in the study will be excluded from the study.

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

40 participants in 2 patient groups

with pause- without pause
Active Comparator group
Description:
Start with an expiratory pause during aspiration and after 6hours the aspiration is performed without an expiratory pause
Treatment:
Other: with pause- without pause
without pause - with pause
Active Comparator group
Description:
Start without an expiratory pause during aspiration and after 6hours the aspiration is performed with an expiratory pause
Treatment:
Other: without pause-with pause

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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