Effect of Co-administration Lidocaine and Dexmedetomidine on Quality of Recovery

Anqing Municipal Hospital

Status: Completed

Conditions: Dexmedetomidine; Lidocaine; Quality of Recovery(QoR-40), Preoperative and Postoperative

Treatments: Drug: Lidocaine infusion; Drug: Co-administration Lidocaine and Dexmedetomidine; Drug: Saline infusion; Drug: Dexmedetomidine infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT04706767

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Details and patient eligibility

About

BACKGROUND: Some studies have revealed that intravenous (IV) lidocaine or dexmedetomidine might improve the quality of recovery undergoing laparoscopic surgery. The investigators investigated whether co-administration lidocaine and dexmedetomidine could better improve the the quality of recovery after laparoscopic total hysterectomy.

METHODS: One hundred and forty-four women with elective laparoscopic total hysterectomy were randomly divided into four groups: Patients in group L received a bolus infusion of lidocaine (2%; 1.5 mg/kg over 10 min before the induction of anesthesia), and then lidocaine was infused at a rate of 1.5 mg/kg/h until close the pneumoperitoneum. Patients in group D received a bolus infusion of dexmedetomidine (0.5 µg/kg over 10 min before the induction of anesthesia), and then dexmedetomidine was infused at a rate of 0.4 μg/kg/h until close the pneumoperitoneum. Patients in group LD received a bolus infusion of lidocaine (2%; 1.5 mg/kg) and dexmedetomidine (0.5 µg/kg) over 10 min before the induction of anesthesia, and then lidocaine and dexmedetomidine were infused at a rate of 1.5 mg/kg/h and 0.4 µg/kg/h until close the pneumoperitoneum, respectively. Patients in group C received the same volume of normal saline 10 min before the induction of anesthesia, and then normal saline (0.9%) was continuously infused in an equal volume until close the pneumoperitoneum. Primary outcome was the quality of recovery (QoR-40) at 1 day prior to sugery, 1 day after sugery, and 2 days after sugery. The secondary outcomes included perioperative remifentanil consumption, postoperative VAS scores, the incidence of postoperative nausea and vomiting, postoperative rescue analgesics and anti-emetics, recovery time, extubation time, and Ramsay sedation scale at 5 min, 10min, 30 min, 60 min after extubation.

Enrollment: 160 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical statusⅠand Ⅱ
• Scheduled for elective laparoscopic total hysterectomy

Exclusion criteria

• History of allergy to local anesthetics
• BMI>30
• Severe respiratory disease
• Renal or hepatic insufficiency
• History of preoperative opioids medication and psychiatric
• preoperative bradycardia
• preoperative atrioventricular block

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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160 participants in 4 patient groups

Effect of Co-administration Lidocaine and Dexmedetomidine on Quality of Recovery

Experimental group

Treatment:

Drug: Co-administration Lidocaine and Dexmedetomidine

Drug: Dexmedetomidine infusion

Drug: Lidocaine infusion

Drug: Saline infusion

Effect of Dexmedetomidine infusion on Quality of Recovery

Experimental group

Treatment:

Drug: Co-administration Lidocaine and Dexmedetomidine

Drug: Dexmedetomidine infusion

Drug: Lidocaine infusion

Drug: Saline infusion

Effect of Lidocaine infusion on Quality of Recovery

Experimental group

Treatment:

Drug: Co-administration Lidocaine and Dexmedetomidine

Drug: Dexmedetomidine infusion

Drug: Lidocaine infusion

Drug: Saline infusion

Effect of saline infusion on Quality of Recovery

Experimental group

Treatment:

Drug: Co-administration Lidocaine and Dexmedetomidine

Drug: Dexmedetomidine infusion

Drug: Lidocaine infusion

Drug: Saline infusion