Effect of Coenzyme Q10 Administration on Polycystic Ovary Syndrome (PCOS)

University of Faisalabad

Status: Not yet enrolling

Conditions: Polycystic Ovarian Syndrome (PCOS)

Treatments: Dietary Supplement: Coenzyme Q10

Study type: Interventional

Funder types: Other

Identifiers

NCT06659406

Tuf/IRB/275/24

Details and patient eligibility

About

The goal of this clinical trial is to determine the effects of coenzyme Q10 supplementation on oxidative stress, inflammation and hyperandrogenism in women with polycystic ovary syndrome. The main questions it aims to answer are:

Does Coenzyme Q10 alter oxidative stress, inflammation and hyperandrogenism in women with Polycystic ovary syndrome.

Participants will take Coenzyme Q10 200mg, once daily for a period of 3 months. The participants will be reassessed after 12 weeks by measuring Malondialdehyde MDA, C-reactive protein CRP, Sex hormone binding globulin SHBG.

Enrollment: 30 estimated patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Married Patients that presented with anovulatory infertility due to PCOS.
• Unmarried Patients that presented with symptoms due to PCOS
• All patients should fulfill Rotterdam criteria for PCOS

Exclusion criteria

• Male factor infertility ( oligospermia or aspermia)
• Tubal factor infertility (abnormal hysterosalpingography)
• Diabetes mellitus, thyroid dysfunction, cardiovascular diseases, impairment of hepatic and renal function
• Autoimmune and Inflammatory disorders
• Abnormal serum prolactin level
• Smokers
• Alcoholic beverage use
• Use of anti diabetic, anti-obesity drugs, insulin or vitamin and mineral supplements

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

30 participants in 1 patient group

CoQ-10 supplementation

Experimental group

Description:

The experimental arm will consist of fertile females diagnosed with polycystic ovary syndrome aged between 18 to 50 years. Patients with diabetes mellitus, thyroid dysfunction, cardiovascular diseases, impairment of hepatic and renal function, autoimmune and Inflammatory disorders will be excluded.

Treatment:

Dietary Supplement: Coenzyme Q10