Effect of Colchicine On Left Ventricle Function After Anterior Myocardial Infarction Assessed By Speckle Tracking

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: Colchicine; Anterior MI

Treatments: Drug: Colchicine 0.5 mg Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT05200052

FMASUMD88/2020

Details and patient eligibility

About

Effect of colchicine use on Left ventricles systolic function in patients with anterior S-T elevation myocardial infarction undergoing primary Percutaneous coronary intervention by using speckle tracking Echocardiography longitudinal strain pattern

Full description

The study participants are patients presented with anterior myocardial infarction.

They will be divided into 2 groups. The first group will receive colchicine loading dose of 1mg then 0.5 mg maintenance dose in addition to the standard anti ischemic treatment for 6 months.

The other group will only receive the standard anti ischmic treatment. Speckle tracking echocardiography will be done to all patients to assess left ventricular longitudinal strain pattern.

Enrollment: 100 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

▪︎Anterior S-T segment elevation myocardial infarction with time of presentation less than 12 hours.

Exclusion criteria

• Severe renal impairment.
• Cardiac arrest.
• Cardiogenic shock.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Colchicine 0.5 mg oral tablet

Active Comparator group

Description:

100 patients presented with anterior Myocardial infarction undergoing primary Percutaneous coronary intervention will receive colchicine tablet 1mg loading dose and colchicine 0.5 mg maintance dose for 6 months and will do longitudinal strain pattern echocardiography to asses left ventricles systolic function

Treatment:

Drug: Colchicine 0.5 mg Oral Tablet

Standard anti ischemic treatment

No Intervention group

Description:

100 patients presented with anterior myocardial infarction undergoing primary percutaneous coronary intervention will do longitudinal strain pattern echocardiography to asses left ventricles systolic function