Effect of Collagen Peptides on Skin Health: A Clinical Trial (BCP-Skin)

Collagen Research Institute

Status: Completed

Conditions: Age-related Changes in Skin Appearance and Physiology

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Specific Collagen Peptides

Study type: Interventional

Funder types: Industry

Identifiers

NCT07516756

SECCR2024-97-01

Details and patient eligibility

About

The goal of this clinical trial is to evaluate whether daily oral supplementation with 2.5 g of specific bioactive collagen peptides (SCP) can improve skin physiology in healthy adult women aged 35-55 years. The main questions it aims to answer are:

Does SCP supplementation increase skin hydration and barrier function? Does SCP improve skin elasticity, firmness, and collagen content? Does SCP reduce the appearance of periorbital wrinkles and improve overall skin appearance? Researchers will compare SCP supplementation to a placebo (a look-alike substance containing no collagen peptides) to see if SCP supports skin structure and appearance over eight weeks.

Participants will:

Consume one sachet of SCP or placebo daily for eight weeks Attend three study visits at baseline, week 4, and week 8 for facial imaging, instrumental skin measurements, and expert assessments Have objective measures taken, including skin hydration, transepidermal water loss, elasticity, firmness, dermal collagen content, and 3D wrinkle morphology Complete subjective skin assessments rated by trained evaluators using a visual analogue scale Report any adverse events or intolerance reactions at each visit This study is designed to provide an integrated evaluation of multiple skin parameters, including barrier function, biomechanical properties, dermal matrix composition, and wrinkle characteristics, in a single trial. By combining objective and subjective measures, the study aims to generate robust and clinically interpretable evidence for the effects of oral collagen peptide supplementation on skin health.

Full description

This clinical trial investigates whether daily oral supplementation with specific bioactive collagen peptides (SCP) can support healthy skin in adult women. Skin aging is a natural process influenced by genetics, hormones, and lifestyle, leading to wrinkles, reduced elasticity, and changes in skin structure. Collagen is a key protein that helps maintain skin strength and elasticity, and its levels decline with age.

The study will evaluate the effects of an 8-week course of SCP supplementation compared to a placebo in healthy women aged 35-55 years. Researchers aim to determine whether oral collagen peptides can improve skin hydration, elasticity, firmness, and overall appearance. This trial combines multiple objective and subjective measures to provide a comprehensive assessment of skin health, offering insights into non-invasive nutritional strategies to maintain skin structure and appearance over time.

The findings from this study are expected to enhance understanding of how collagen peptides affect skin physiology and contribute to evidence-based recommendations for supporting healthy skin.

Enrollment: 66 patients

Sex: Female

Ages: 35 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Fitzpatrick skin type III-IV
• Presence of crow's feet wrinkles graded 2-4
• Presence of under-eye fine lines graded 2-5
• Generally in good health
• Able to comply with study procedures and visit schedule

Exclusion criteria

• Use of systemic or topical anti-inflammatory medication, including corticosteroids, within the 4 weeks prior to baseline
• Known hypersensitivity or allergy to any ingredient of the investigational products
• Pregnancy, breastfeeding, or intention to become pregnant during the study period
• History of relevant dermatological conditions: psoriasis, eczema, atopic dermatitis, or severe acne
• Presence of birthmarks, hyperpigmentation, active inflammation, or other visible skin abnormalities in the test areas
• Recent aesthetic procedures Use of anti-aging or topical treatments
• Intake of nutritional supplements
• Participation in other clinical studies within the past 2 months
• Significant lifestyle or dietary changes during the study period
• Excessive UV exposure
• Systemic diseases, including heart, immune, vascular, liver, gallbladder, or kidney disorders
• Known allergies to foods, cosmetics, skincare products, or topical medications
• Any other condition that, in the investigator's opinion, would make the participant ineligible

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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66 participants in 2 patient groups, including a placebo group

Specific Collagen Peptides

Experimental group

Description:

Participants in this arm receive 2.5 g of specific bioactive collagen peptides (VERISOL®) once daily for 8 weeks. The powder is dissolved in warm water and consumed orally. The supplement contains defined collagen peptides derived from bovine type I collagen, which have been shown to support skin hydration, elasticity, firmness, dermal collagen content, and wrinkle reduction. Participants continue their usual lifestyle habits while taking the supplement.

Treatment:

Dietary Supplement: Specific Collagen Peptides

Maltodextrin

Placebo Comparator group

Description:

Participants in this arm receive a matching placebo sachet once daily for 8 weeks. The placebo contains plant-derived maltodextrin and is identical in appearance, taste, and texture to the collagen peptide supplement. It is dissolved in warm water and consumed orally. Participants continue their usual lifestyle habits while taking the placebo.

Treatment:

Dietary Supplement: Placebo