Effect of Collagen Supplementation on Tendinopathy

Bispebjerg Hospital

Status: Active, not recruiting

Conditions: Tendinopathy

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Hydrolyzed collagen; Other: Heavy slow resistance training

Study type: Interventional

Funder types: Other

Identifiers

NCT04578418

H-16019857

Details and patient eligibility

About

Tendon injuries represent a significant problem in elite athletes. Therefore, prevention and effective treatment of tendon overload injury/tendinopathy is important. Among different treatment options, heavy-slow loading based rehabilitation is considered among the most efficient treatments in athletes. In this study, we will investigate if supplementation with hydrolyzed collagen in combination with a heavy-slow loading based 12 weeks rehabilitation regime can improve treatment of tendon overload injury/tendinopathy. The investigators will examine elite athletes with overload injury/tendinopathy with regards to symptoms (pain, function), tendon morphology (ultrasonography), and vascularization (Doppler US). The investigators hypothesize that collagen supplementation can have an improving effect on tendon pain and function. Thus, the investigation will show if a rehabilitation regime of collagen supplementation combined with heavy-slow mechanical loading can improve tendon healing compared to mechanical loading alone.

Full description

Randomized placebo-controlled intervention study with follow-up after one month

Enrollment: 64 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elite athletes
• 18-40 years old
• Exercise related tendon pain on one or both legs
• Soreness during physical examination of tendon upon palpation
• Uni- or bilateral tendinopathy symptoms > 3 months

Exclusion criteria

• Previous tendon surgery
• Diabetes
• Arthritis
• Corticosteroid injection for tendinopathy within the last 3 months
• Any form of tendon injection within the last 3 months
• Smoking

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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64 participants in 2 patient groups

Collagen + heavy slow resistance group

Active Comparator group

Description:

Daily collagen supplementation + heavy slow resistance training three times weekly for 12 weeks.

Treatment:

Other: Heavy slow resistance training

Dietary Supplement: Hydrolyzed collagen

Placebo + heavy slow resistance group

Experimental group

Description:

Daily placebo supplementation + heavy slow resistance training three times weekly for 12 weeks.

Treatment:

Other: Heavy slow resistance training

Dietary Supplement: Placebo