Effect of Combined Exercise Training in Patients With Multiple Sclerosis

Uskudar University

Status: Not yet enrolling

Conditions: Multiple Sclerosis

Treatments: Other: Home program; Other: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06595394

sarcopenicms11

Details and patient eligibility

About

The aim of this clinical trial is exercise in sarcopenic MS patients to demonstrate the effectiveness of education. The main questions it aims to answer are: -Can exercise training make a change in muscle thickness in sarcopenic MS patients?

--Does exercise training have an effect on balance in sarcopenic MS patients?

• Does exercise training have an effect on the risk of falling in sarcopenic MS patients?

Participants will:

They will continue combined exercise applications 3 days a week for 8 weeks. Evaluations will be made before the application and at the end of the 8 weeks. The data will be analyzed afterwards.

Full description

A significant decrease in physical performance is observed in MS patients. The reasons for this can be changes in muscle contractile structures and symptoms such as sarcopenia. Sarcopenia is a disorder characterized by loss of skeletal muscle mass and decrease in muscle strength and physical performance. Loss of muscle mass seen outside of old age is defined as secondary sarcopenia. In recent years, studies on neurological disorders and their relationship with sarcopenia have increased. Early diagnosis of sarcopenia in neurological patients and implementation of applications aimed at this are important from an early stage. The aim of this study is to examine the effect of exercise training in sarcopenic MS patients. In the study, participants will be applied a combined exercise program 3 days a week for 8 weeks. Parameters such as muscle thickness, balance, and fall risk will be evaluated before and after physiotherapy application including aerobic exercise, balance exercises, and strengthening exercises.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• People diagnosed with MS by a neurologist
• People with ambulation whose EDSS is 4.5 or below
• People between the ages of 18-50
• People who do not exercise regularly and are not included in an exercise program

Exclusion criteria

• Having been diagnosed with sarcopenia before MS diagnosis
• Having had an MS attack within the last 30 days
• Having any musculoskeletal problems that may affect walking and balance
• Having a diagnosed psychiatric disease that may affect cognitive status
• Having a neurological disease other than MS

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Interventional group

Experimental group

Description:

Participants were given combined exercise training 3 days a week.

Treatment:

Other: Exercise

Control group

Active Comparator group

Description:

Participants were followed with a home program 3 days a week.

Treatment:

Other: Home program