Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery

Yonsei University

Status and phase

Completed

Phase 4

Conditions

Heart Valve Diseases

Treatments

Procedure: remote ischemic pre and postconditioning (RIPC)

Study type

Interventional

Funder types

Other

Identifiers

NCT01427621

4-2009-0648

Details and patient eligibility

About

Pulmonary dysfunction after cardiac surgery with CPB remains to be a problem complicating the postoperative course of the patients. The investigators hypothesized that RIPCcom, combined intervention of remote ischemic preconditioning and remote ischemic postconditioning, would confer beneficial influence on inflammatory response and resultant postoperative pulmonary dysfunction after CPB in patients undergoing complex valvular heart surgery who are at increased risk of postoperative pulmonary dysfunction.The aim of this study was to evaluate the lung-protective effect of combined remote ischemic pre- and post-conditioning in patients undergoing complex valvular heart surgery.

Enrollment

54 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients undergoing valvular heart surgery.
Age: 20~80.

Exclusion criteria

Emergency operation.
patients with peripheral vascular disease.
Patients with a known history or clinical evidence of chronic obstructive pulmonary disease.
Patients with hepatic or renal dysfunction
Patients with acute myocardial infarction within 1 week before surgery