Effect of Combined Therapy on Neglect Syndrome in Stroke Patients

Chang Gung Medical Foundation

Status: Completed

Conditions: Cerebrovascular Accidents

Treatments: Other: CIT; Other: conventional therapy; Other: EP

Study type: Interventional

Funder types: Other

Identifiers

NCT00784706

97-1391B

Details and patient eligibility

About

The purpose of the current study is to evaluate motor and neglect recovery of stroke patients produced by CIT using kinematic and oculomotor assessment, together with conventional clinical measures.

Full description

This project will be carried out using a short term constraint and training protocol targeting at subacute and chronic patients with motor and perceptual deficits. The outcome measures will include kinematic and oculomotor analyses, which have not been employed yet.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• a clinical cerebrovascular of right cerebral accident patients
• the age over 18-year-old
• demonstration of Brunnstrom stage III of the affected upper extremity
• patients with perceptual deficits
• no severe cognitive disorder, could understand and follow orders
• no severe equilibrium problems which will influence the intervention

Exclusion criteria

• recurrent of the stroke or epilepsy during the intervention
• patients with the neurological or psychical history, for example, alcoholism, drug poisoning or bipolar disorder
• injected the Botox into the affected upper extremity during the past 6 months
• participate in the other interventional study in the same time
• refuse subscribed the informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups

CIT with eye-patching

Experimental group

Description:

The CIT addressed forced use of the affected UE and restricted the unaffected UE during training. Shaping skills were delivered while participants were forced to use their affected UE in the mass practice of functional tasks, such as drinking water and opening a jar. Participants wore a mitt on their unaffected hand and wrist for 6 hours/day during the 3-week training and reported their compliance in a daily log. Participants were also asked to wear glasses with a patch on the right lens to block the visual stimuli from the right side and force them to receive the stimuli from the left-side visual field.

Treatment:

Other: EP

Other: CIT

constraint-induced therapy

Experimental group

Description:

The intervention in this group resembled the intervention of the CIT+EP group, except participants did not wear the EP glasses.

Treatment:

Other: CIT

conventional therapy

Active Comparator group

Description:

traditional occupational therapy matched in intensity and duration with the other groups. The training program included stretching and weight bearing of the affected UE, improving the range of motion of the affected UE, muscle strengthening, and the practice of tasks used for functional training might involve the unaffected UE to assist in the affected UE; for example, stabilizing a bottle while opening its lid or moving pegs into holes on a board.

Treatment:

Other: conventional therapy