Effect of Combined Use of Ivermectin and Colchicine in COVID-19 Patients

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: COVID-19

Treatments: Drug: Ivermectin + colchicine; Drug: Colchicine

Study type: Interventional

Funder types: Other

Identifiers

NCT05246072

FAMSU R 179 / 2021

Details and patient eligibility

About

The aim of this study will be to investigate the efficacy of use of combination of Ivermectin and colchicine on severity and outcome Of COVID 19 infection.

Enrollment: 135 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Willing and able to provide written informed consent prior to performing study procedures.
• Currently hospitalized and requiring medical care for non-sever COVID-19.
• One or more of the following: (positive PCR test or positive antibodies) or (CT Chest consistent with COVID19 infection).

Exclusion criteria

• Tocilizumab use.
• Mechanical ventilation
• Requirement of oxygen supplementation >8L/min on admission

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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135 participants in 3 patient groups

Ivermectin + colchicine + standard care

Active Comparator group

Description:

In addition to the local standard of care for COVID 19 patients, the patient will receive: Ivermectin + Colchicine

Treatment:

Drug: Ivermectin + colchicine

Colchicine + standard care

Active Comparator group

Description:

In addition to the local standard of care for COVID 19 patients, the patient will receive: Colchicine

Treatment:

Drug: Colchicine

standard care

No Intervention group

Description:

Patients will receive Standard care