Effect of Common Analgesia on Pulp Sensibility

HITEC-Institute of Medical Sciences

Status: Completed

Conditions: Irreversible Pulpitis With Apical Periodontitis

Treatments: Drug: Paracetamol 500 mg; Drug: Ibuprofen 400 mg (if necessary)

Study type: Interventional

Funder types: Other

Identifiers

NCT07125911

Dr Kinza Iftikhar

Details and patient eligibility

About

his study will investigate whether commonly used analgesics - 400 mg ibuprofen and 500 mg paracetamol - influence the accuracy of pulpal sensibility tests (cold test and electric pulp test) in patients with symptomatic irreversible pulpitis. Analgesics are often taken prior to dental visits and may mask endodontic symptoms, affecting diagnosis. Participants will be randomly assigned to receive either ibuprofen or paracetamol in a double-blind design. Test responses and pain levels will be measured before and 30 minutes after medication to assess any masking effect.

Enrollment: 122 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with moderate to severe pain due to SIP

Patients with prolonged pain in response to the cold test with Endo-Ice

Patients who had not used any analgesics or CNS depressant during last 6 hours

Males and females aged 18-40

Exclusion criteria

• patients with American Society of Anesthesiologists physical status>1

who could not take paracetamol and ibuprofen

whose teeth did not respond to the cold test

with toothache due to periapical disease

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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122 participants in 2 patient groups

Ibuprofen 400 mg

Experimental group

Description:

Participants will receive a single oral dose of 400 mg ibuprofen. Cold test and electric pulp test (EPT) will be performed on a tooth with symptomatic irreversible pulpitis and on a contralateral healthy tooth before drug administration and 30 minutes after ingestion.

Treatment:

Drug: Ibuprofen 400 mg (if necessary)

Paracetamol 500 mg

Experimental group

Description:

Participants will receive a single oral dose of 500 mg paracetamol. Cold test and electric pulp test (EPT) will be performed on a tooth with symptomatic irreversible pulpitis and on a contralateral healthy tooth before drug administration and 30 minutes after ingestion.

Treatment:

Drug: Paracetamol 500 mg