Effect of Commute Traffic on Vascular Function

University of Washington

Status: Completed

Conditions: Cardiovascular Diseases

Treatments: Other: Filtered Air

Study type: Interventional

Funder types: Other; Other U.S. Federal agency; NIH

Identifiers

NCT05454930

RD-83479601 (Other Grant/Funding Number)

STUDY00001196

K24ES013195 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The investigators will assess the vascular effects of riding in a car in heavily trafficked roadways, and whether filtering the car's air reduces those effects.

Full description

In this double-blind, crossover trial, randomized to order, recruited participants will be screened and then will accompany the study team on three typical commutes on separate days with sufficient washout (i.e., three weeks) between drives. One day this will occur with an effective filter system in the vehicle and the other two days without effective filtration; ineffective filtration is the most typical actual vehicle condition. Subjects will be unaware of the filtration conditions of the commute on that day. Each subject's experimental sessions will occur at the same time of day and will be separated by at least 21 days. The two sessions (either filtered air or traffic-derived entrained air) will be 120 minutes in duration and will encompass routes on heavily traveled roadways in the Seattle area. Before subjects begin the commute trials, they will go through the consent process and a series of screening tests. The study investigators will assess a series of measures regarding vascular function before and after each drive.

Enrollment: 16 patients

Sex: All

Ages: 18 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy

Exclusion criteria

• asthma,
• high blood pressure,
• diabetes,
• high cholesterol,
• other chronic conditions requiring ongoing medical care.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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16 participants in 2 patient groups

Typical Commute

No Intervention group

Description:

Participants spend two hours in automobile, on heavily trafficked roadways, without active filtration of air pollutants

Typical Commute, Filtered Air

Other group

Description:

Participants spend two hours in automobile, on heavily trafficked roadways, with active filtration of air pollutants

Treatment:

Other: Filtered Air