Effect of Composition and Timing of Ingestion of Fluids on the Urinary Excretion of Lithogenic Substances

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Completed

Conditions: Healthy

Treatments: Other: Water

Study type: Interventional

Funder types: Other

Identifiers

NCT03447847

43111/16

Details and patient eligibility

About

Interventional crossover study on healthy volunteers aimed at evaluating the effect of the composition and timing of ingestion of different types of water on the urinary excretion of lithogenic substances; the study will also analyze the effect of potassium citrate on urine pH and lithogenic substances

Enrollment: 12 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age >18 years

Exclusion criteria

• Chronic malabsorption
• Recurrent urinary tract infections
• History of kidney stones

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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12 participants in 4 patient groups

Phase 1

Experimental group

Description:

A=oligomineral water, B=oligomineral water

Treatment:

Other: Water

Phase 2

Experimental group

Description:

A=oligomineral water, B=bicarbonate-rich water

Treatment:

Other: Water

Phase 3

Experimental group

Description:

A=bicarbonate-rich water, B=oligomineral water

Treatment:

Other: Water

Phase 4

Experimental group

Description:

A=bicarbonate-rich water, B=bicarbonate-rich water

Treatment:

Other: Water