Effect of Consuming Oat Bran Mixed in Water Before a Meal on Glycemic Responses in Healthy Humans - a Pilot Study

Glycemic Index Laboratories

Status: Completed

Conditions: Glucose Intolerance

Treatments: Other: 0 grams oat bran; Other: 27.3 grams oat bran; Other: 4.5 grams oat bran; Other: 13.6 grams oat bran

Study type: Interventional

Funder types: Industry

Identifiers

NCT02801916

GIL1527b

Details and patient eligibility

About

Viscous dietary fibers including oat β-glucan are one of the most effective classes of functional food ingredients for reducing postprandial blood glucose. The mechanism of action is thought to be via an increase in viscosity of the stomach contents that delays gastric emptying and reduces mixing of food with digestive enzymes, which, in turn, retards glucose absorption. Previous studies suggest that taking viscous fibers separate from a meal may not be effective in reducing postprandial glycemia. The purpose of this study is to re-assess the effect of consuming a preload of a commercially available oat-bran (4.5, 13.6 or 27.3 g) containing 22% of high molecular weight oat β-glucan (O22) mixed in water before a test-meal of white bread on glycemic responses in 10 healthy humans.

Enrollment: 10 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects

Exclusion criteria

• Pregnancy
• Diabetes
• Recent medical or surgical hospitalization
• Use of drugs influencing glucose metabolism
• Use of drugs influencing gastrointestinal function
• Allergy to oats or wheat

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Study subjects

Other group

Description:

Each healthy subject will receive each of the interventions in randomized order.

Treatment:

Other: 0 grams oat bran

Other: 27.3 grams oat bran

Other: 13.6 grams oat bran

Other: 4.5 grams oat bran