Effect of Contrast Medium on Optic Nerve Sheath Diameter

Keimyung University

Status: Completed

Conditions: Optic Nerve Sheath Diameter

Treatments: Other: thoracic epidural catheterization

Study type: Interventional

Funder types: Other

Identifiers

NCT04826042

2021-01-042

Details and patient eligibility

About

One method of indirect measurement of intracranial pressure is using optic nerve sheath diameter. There is no study whether equal volume of contrast medium injection has any increasing effect of optic nerve sheath diameter.

This study is designed to measure the changes of optic nerve sheath diameter and cerebral oxygenation when equal volume of contrast medium or normal saline was injected in epidural space.

Full description

Previous study showed that different volume of injections (1.0 ml/kg vs. 1.5 ml/kg) during caudal anesthesia showed siginifiant increase of optic nerve sheath diameter in group of high volumes. Increase of ICP can result in harmful effect including reduced cerebral flow and oxygen saturation. Also, increase of ICP can cause headache, syncope and transient loss of visual acuity. The proven and valid method of measuring ICP indirectly is using optic nerve sheath diameter. This study was designed to examine the changes of optic nerve sheath diameter and cerebral oxygenation when equal volume of contrast medium or normal saline was injected in epidural space.

Enrollment: 42 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• lung cancer
• liver cancer
• stomach cancer
• pancreas cancer
• gallbladder

Exclusion criteria

• coagulopathy
• infection
• previous spine fusion at thoracic level
• previous brain lesion

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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42 participants in 2 patient groups, including a placebo group

contrast group

Active Comparator group

Description:

injection of contrast medium 6 cc during thoracic epidural catheterization

Treatment:

Other: thoracic epidural catheterization

normal saline group

Placebo Comparator group

Description:

injection of normal saline 6 cc during thoracic epidural catheterization

Treatment:

Other: thoracic epidural catheterization